Prof. Dr. rer. nat. Hauke Busch

University of Lübeck
Lübeck Institute of Experimental Dermatology
23562 Lübeck
Gebäude 67 2.OG, Raum 41

Phone:+49 (0) 451 3101 8470
Fax:+49 (0) 451 3101 8404



Prof. Busch studied Theoretical Physics at the Technical University of Darmstadt, Germany, and Trinity College Dublin, Ireland. After finishing his PhD in 2004, dealing with  numerical simulations on the interplay of noise and neuronal excitation, he started in the field of Systems Biology as a PostDoc at the Center for Modelling and Simulation in the Biosciences, University of Heidelberg, and German Cancer Research Center. His primary focus was on the development and simulation of protein signaling pathway models and gene regulatory networks. In 2009 he became a Junior research fellow at the Freiburg Institute of Advanced Studies (FRIAS) at the University of Freiburg.

Together with Dr. Dr. Melanie Börries he established a joint dry- and wet-lab at the Center for Biosystems Analysis (ZBSA), wherein they combined experimental research on cell-cell communication with the development of appropriate multi-scale dynamic models to investigate the necessary and sufficient control points that lead to cell proliferation, differentiation, migration or death.

In 2013, they moved their lab to the German Cancer Consortium partner site Freiburg at the Institute of Molecular Medicine and Cell Research, developing analysis pipelines for the stratification, diagnosis and therapy prediction of cancer patients based on sequencing technology.

Since October 2016, Prof. Busch is a newly appointed member of the Lübeck Institute of Experimental Dermatology and Member of the Excellence Cluster "Inflammation at Interfaces", carrying over his Systems Biology approaches to study autoimmune diseases.


Selected publications

  • Arif M A, Hiss M, Tomek M, Busch H, Tintelnot S, Meyberg R, Reski R, Rensing S, Frank W. ABA-induced vegetative diaspore formation in Physcomitrella patens. Frontiers in Science. 2019
  • Staats S, Wagner A E, Lüersen K, Künstner A, Meyer T, Kahns A K, Derer S, Graspeuntner S, Rupp J, Busch H.  Dietary ursolic acid improves health span and life span in male Drosophila melanogaster. BioFactors. 2019
  • Hirose M, Schilf P, Zarse K, Busch H, Fuellen G, Jöhren O, Köhling R, König I.  Maternally Inherited Differences within Mitochondrial Complex I Control Murine Healthspan. Genes. 2019

  • Pazzagli C, He Y, Busch H, Esser P, Kiritsi D, GacheY, et al.  Absence of the Integrin α3 Subunit Induces an Activated Phenotype in Human Keratinocytes.  Journal of Investigative Dermatology. 2017

  • Strotbek M, Schmid S, Sánchez‐González I, Boerries M, Busch H, et al. miR‐181 elevates Akt signaling by co‐targeting PHLPP2 and INPP4B phosphatases in luminal breast cancer. International Journal of cancer. 2017

  • Mitschke J,  Losada ML,  Schmalhofer O,  Boerries M, Busch H, et al.  The EMT-activator Zeb1 is a key factor for cell plasticity and promotes metastasis in pancreatic cancer AM Krebs. Nature Cell Biology 2017

  • Andrlová H,  Mastroianni J, Madl J, Kern J, Melchinger W,  Dierbach H, Busch H, et al. Biglycan expression in the melanoma microenvironment promotes invasiveness via increased tissue stiffness inducing integrin-β1 expression. Oncotarget. 2017

  • Nkuipou-Kenfack E, Schanstra J, Bajwa S, Pejchinovski M, Vinel C, Dray C, Valet P, Bascands J, Vlahou A, Koeck T, Borries M, Busch H, Bechtel-Walz W. The use of urinary proteomics in the assessment of suitability of mouse models for ageing. Plos one. 2017

  • Hirose M,  Schilf P, Gupta Y, Zarse K, Kuenstner A, Busch H, Yin J, et al. Low-level mitochondrial heteroplasmy modulates DNA replication, glucose metabolism and lifespan in mice. Scientific Reports. 2017

  • Adlung L, Kar S, Wagner M, She B, Chakraborty S, Bao J, Lattermann S, Boerries M, Busch H,  Wuchter P, D Ho A, Timmer J, Schilling M, Höfer T, Klingmüller U.  Protein abundance of AKT and ERK pathway components governs cell type‐specific regulation of proliferation. Molecular systems biology. 2017

  • Lerchenmüller C, Heißenberg J, Damilano F, Bezzeridis V.J, Krämer I, Bochaton-Piallat M.-L, Hirschberg K, Busch M, Katus H.A., Peppel K, Busch H,  et al. S100A6 Regulates Endothelial Cell Cycle Progression by Attenuating Antiproliferative Signal Transducers and Activators of Transcription 1 Signaling. ATVB. 2016

  • Offermann B, Knauer S, Singh A, Fernández-Cachón M.L., Klose M, Kowar S, Busch H, Boerries M. Boolean Modeling Reveals the Necessity of Transcriptional Regulation for Bistability in PC12 Cell Differentiation. Frontiers in genetics. 2016

  • Boerries M, Grahammer F, Eiselein S, Buck M, Meyer C, Goedel M, Bechtel W, Zschiedrich S, Pfeifer D, Laloë D, et al. Molecular fingerprinting of the podocyte reveals novel gene and protein regulatory networks. Kidney International. 2013

  • Singh A, Nascimento J.M., Kowar S, Busch H, Boerries M. Boolean approach to signalling pathway modelling in HGF-induced keratinocyte migration. Bioinformatics. 2012

  • Mesecke S, Urlaub D, Busch H, Eils R, Watzl, C. Integration of Activating and Inhibitory Receptor Signaling by Regulated Phosphorylation of Vav1 in Immune Cells. Science Signaling. 2011

  • Busch H, Camacho-Trullio D, Rogon Z, Breuhahn K, Angel P, Eils R, Szabowski A. Gene network dynamics controlling keratinocyte migration. Molecular Systems Biology. 2008